New techniques developed for prion detection in blood and cerebrospinal fluid
نویسندگان
چکیده
منابع مشابه
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متن کاملDiagnostic and prognostic value of human prion detection in cerebrospinal fluid.
OBJECTIVE Several prion amplification systems have been proposed for detection of prions in cerebrospinal fluid (CSF), most recently, the measurements of prion seeding activity with second-generation real-time quaking-induced conversion (RT-QuIC). The objective of this study was to investigate the diagnostic performance of the RT-QuIC prion test in the broad phenotypic spectrum of prion disease...
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A rapid, simple and reproducible HPLC method was developed and validated for the analysis of nimodipine (NM) and/or its metabolite, oxidized nimodipine (OX–NM) in rat cerebrospinal fluid (CSF) and artificial CSF. The NM and OX–NM were eluted in less than 10 min with no interferences from the endogenous CSF peaks. Analysis was carried out on a Eurospher Performance (RP-C18, 250 × 4.6 mm) column ...
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ژورنال
عنوان ژورنال: Nature Reviews Neurology
سال: 2011
ISSN: 1759-4758,1759-4766
DOI: 10.1038/nrneurol.2011.26